Association of IFITM3 rs12252 polymorphisms, BMI, diabetes, and hypercholesterolemia with mild flu in an Iranian population
Identifieur interne : 000F27 ( Main/Exploration ); précédent : 000F26; suivant : 000F28Association of IFITM3 rs12252 polymorphisms, BMI, diabetes, and hypercholesterolemia with mild flu in an Iranian population
Auteurs : Parvaneh Mehrbod [Iran] ; Sana Eybpoosh [Iran] ; Fatemeh Fotouhi [Iran] ; Hadiseh Shokouhi Targhi [Iran] ; Vahideh Mazaheri [Iran] ; Behrokh Farahmand [Iran]Source :
- Virology Journal [ 1743-422X ] ; 2017.
Abstract
We conducted a case-control study, including 79 mild flu and 125 flu-negative individuals attending primary care centers of three provinces of Iran (
All participants were of Fars ethnic background. The allele frequency for rs12252-C was found to be 9.49% among cases and 2.40% among controls. Carriers of the rs12252 C allele (CT + CC genotypes) showed 5.92 folds increase in the risk of mild flu comparing to the T allele homozygotes (
This is the first study evaluating the association between rs12252 polymorphisms, diabetes, hypercholesterolemia, and BMI and susceptibility to mild flu in an Iranian population. Our results suggest a significant positive association between mild flu and rs12252 C allele heterozygous and carriage. Future replication of the strong association observed here between rs12252 C allele carriage and mild flu might candidate this polymorphism as a genetic marker for early screening of susceptibility to mild flu. Lack of significant association between C allele homozygous and mild flu, observed in this study, might be the result of small sample size in this group.
IR.PII.REC.1395.3.
The online version of this article (10.1186/s12985-017-0884-4) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12985-017-0884-4
PubMed: 29121968
PubMed Central: 5680824
Affiliations:
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Institute of Iran,</institution></institution-wrap>Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Tehran</wicri:regionArea></affiliation></author><author><name sortKey="Shokouhi Targhi, Hadiseh" sort="Shokouhi Targhi, Hadiseh" uniqKey="Shokouhi Targhi H" first="Hadiseh" last="Shokouhi Targhi">Hadiseh Shokouhi Targhi</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9562 2611</institution-id><institution-id institution-id-type="GRID">grid.420169.8</institution-id><institution>Influenza and Other Respiratory Viruses Department,</institution><institution>Pasteur Institute of Iran,</institution></institution-wrap>Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Tehran</wicri:regionArea></affiliation></author><author><name sortKey="Mazaheri, Vahideh" sort="Mazaheri, Vahideh" uniqKey="Mazaheri V" first="Vahideh" last="Mazaheri">Vahideh 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Iran,</institution></institution-wrap>Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Tehran</wicri:regionArea></affiliation></author><author><name sortKey="Eybpoosh, Sana" sort="Eybpoosh, Sana" uniqKey="Eybpoosh S" first="Sana" last="Eybpoosh">Sana Eybpoosh</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9562 2611</institution-id><institution-id institution-id-type="GRID">grid.420169.8</institution-id><institution>Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases,</institution><institution>Pasteur Institute of Iran,</institution></institution-wrap>Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Tehran</wicri:regionArea></affiliation></author><author><name sortKey="Fotouhi, Fatemeh" sort="Fotouhi, Fatemeh" uniqKey="Fotouhi F" first="Fatemeh" last="Fotouhi">Fatemeh Fotouhi</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9562 2611</institution-id><institution-id institution-id-type="GRID">grid.420169.8</institution-id><institution>Influenza and Other Respiratory Viruses Department,</institution><institution>Pasteur Institute of Iran,</institution></institution-wrap>Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Tehran</wicri:regionArea></affiliation></author><author><name sortKey="Shokouhi Targhi, Hadiseh" sort="Shokouhi Targhi, Hadiseh" uniqKey="Shokouhi Targhi H" first="Hadiseh" last="Shokouhi Targhi">Hadiseh Shokouhi Targhi</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9562 2611</institution-id><institution-id institution-id-type="GRID">grid.420169.8</institution-id><institution>Influenza and Other Respiratory Viruses Department,</institution><institution>Pasteur Institute of Iran,</institution></institution-wrap>Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Tehran</wicri:regionArea></affiliation></author><author><name sortKey="Mazaheri, Vahideh" sort="Mazaheri, Vahideh" uniqKey="Mazaheri V" first="Vahideh" last="Mazaheri">Vahideh Mazaheri</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9562 2611</institution-id><institution-id institution-id-type="GRID">grid.420169.8</institution-id><institution>Influenza and Other Respiratory Viruses Department,</institution><institution>Pasteur Institute of Iran,</institution></institution-wrap>Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Tehran</wicri:regionArea></affiliation></author><author><name sortKey="Farahmand, Behrokh" sort="Farahmand, Behrokh" uniqKey="Farahmand B" first="Behrokh" last="Farahmand">Behrokh Farahmand</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9562 2611</institution-id><institution-id institution-id-type="GRID">grid.420169.8</institution-id><institution>Influenza and Other Respiratory Viruses Department,</institution><institution>Pasteur Institute of Iran,</institution></institution-wrap>Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Tehran</wicri:regionArea></affiliation></author></analytic><series><title level="j">Virology Journal</title><idno type="eISSN">1743-422X</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1"><italic>IFITM3</italic> has been suggested to be associated with infection in some ethnic groups. Diabetes and hypercholesterolemia are also important clinical conditions that can predispose individuals to infection. The aim of this study was to investigate the association of rs12252 C polymorphism, BMI, diabetes, and hypercholesterolemia with mild flu in an Iranian population.</p></sec><sec><title>Methods</title><p id="Par2">We conducted a case-control study, including 79 mild flu and 125 flu-negative individuals attending primary care centers of three provinces of Iran (<italic>i.e,</italic> Markazi, Semnan, and Zanjan). Pharyngeal swab specimens were collected from all participants, and were subjected to RNA and DNA extractions for Real-time PCR and PCR tests. All PCR products were then sequenced to find T/C polymorphisms in the rs12252 region. Data on demographic, anthropometric, and clinical variables were collected from participants’ medical records available in the primary care centers. The data was analyzed using DNASIS (v. 2.5) and Stata (v.11) software.</p></sec><sec><title>Results</title><p id="Par3">All participants were of Fars ethnic background. The allele frequency for rs12252-C was found to be 9.49% among cases and 2.40% among controls. Carriers of the rs12252 C allele (CT + CC genotypes) showed 5.92 folds increase in the risk of mild flu comparing to the T allele homozygotes (<italic>P</italic> value: 0.007). We also found a significant positive association between rs12252 C allele heterozygote and mild flu (OR: 7.62, <italic>P</italic> value: 0.008), but not in C allele homozygote group (OR: 2.71, <italic>P</italic> value: 0.406). Similarly, we did not find a significant association between mild flu and BMI (OR: 1.06, <italic>P</italic> value: 0.087), diabetes (OR: 0.61, <italic>P</italic> value: 0.392), and hypercholesterolemia (OR: 0.50, <italic>P</italic> value: 0.393) in multivariable logistic regression.</p></sec><sec><title>Conclusions</title><p id="Par4">This is the first study evaluating the association between rs12252 polymorphisms, diabetes, hypercholesterolemia, and BMI and susceptibility to mild flu in an Iranian population. Our results suggest a significant positive association between mild flu and rs12252 C allele heterozygous and carriage. Future replication of the strong association observed here between rs12252 C allele carriage and mild flu might candidate this polymorphism as a genetic marker for early screening of susceptibility to mild flu. Lack of significant association between C allele homozygous and mild flu, observed in this study, might be the result of small sample size in this group.</p></sec><sec><title>Trial registration</title><p id="Par5">IR.PII.REC.1395.3.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (10.1186/s12985-017-0884-4) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Amini Bavil Olyaee, S" uniqKey="Amini Bavil Olyaee S">S Amini-Bavil-Olyaee</name></author><author><name sortKey="Choi, Yj" uniqKey="Choi Y">YJ Choi</name></author><author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name></author><author><name sortKey="Shi, M" uniqKey="Shi M">M Shi</name></author><author><name sortKey="Huang, Ic" uniqKey="Huang I">IC Huang</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M 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López</name></author><author><name sortKey="Hang, Hc" uniqKey="Hang H">HC Hang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Yh" uniqKey="Zhang Y">YH Zhang</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Li, N" uniqKey="Li N">N Li</name></author><author><name sortKey="Peng, Yc" uniqKey="Peng Y">YC Peng</name></author><author><name sortKey="Giannoulatou, E" uniqKey="Giannoulatou E">E Giannoulatou</name></author><author><name sortKey="Jin, Rh" uniqKey="Jin R">RH Jin</name></author><author><name sortKey="Yan, Hp" uniqKey="Yan H">HP Yan</name></author><author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name></author><author><name sortKey="Liu, Jh" uniqKey="Liu J">JH Liu</name></author><author><name sortKey="Liu, N" uniqKey="Liu N">N Liu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Mehrbod, Parvaneh" sort="Mehrbod, Parvaneh" uniqKey="Mehrbod P" first="Parvaneh" last="Mehrbod">Parvaneh Mehrbod</name></noRegion><name sortKey="Eybpoosh, Sana" sort="Eybpoosh, Sana" uniqKey="Eybpoosh S" first="Sana" last="Eybpoosh">Sana Eybpoosh</name><name sortKey="Farahmand, Behrokh" sort="Farahmand, Behrokh" uniqKey="Farahmand B" first="Behrokh" last="Farahmand">Behrokh Farahmand</name><name sortKey="Fotouhi, Fatemeh" sort="Fotouhi, Fatemeh" uniqKey="Fotouhi F" first="Fatemeh" last="Fotouhi">Fatemeh Fotouhi</name><name sortKey="Mazaheri, Vahideh" sort="Mazaheri, Vahideh" uniqKey="Mazaheri V" first="Vahideh" last="Mazaheri">Vahideh Mazaheri</name><name sortKey="Shokouhi Targhi, Hadiseh" sort="Shokouhi Targhi, Hadiseh" uniqKey="Shokouhi Targhi H" first="Hadiseh" last="Shokouhi Targhi">Hadiseh Shokouhi Targhi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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